Formulation and Evaluation of piper betle L. Based Gel Dosage Form Against Propionibacterium Acne

Now a day the majority of Indians are affected by the persistent skin illness know as Acne. Sebaceous glands are involved in the chronic inflammatory skin condition. Acne is an Inflammatory skin disease that occurs due to blockages In polysebaseous and inflammation that occurs by bacteria such as Propionibacterium acne. Ethanolic extract of piper betle L. inhibit the growth of Propionibacterium acne bacteria and show the antiacne activity. It contains additional qualities including anti-ageing, anti-inflammatory, antibacterial, etc. and it typically used to treat acne. Piper betle L. was collected and authenticated and then extracted with maceration method by using Ethanol (95%) as a solvent. The phytoconstituent identification done by phytochemical screening test. We formulated the antiacne gel using ingredient like ethanolic extract of piper betle L. Certain evaluation parameter we tested to check whether cream is suitable for human skin and its antibacterial activity was checked on the micro-organism Propionibacterium acne which is responsible for causing acne. Propionibacterium acne is a bacteria isolated from the acne swab from the person who has acne and cultivate in ASLA agar. We measure the zone of inhibition by agar well diffusion method. The agar well diffusion method is a simple and widely used technique to assess the antimicrobial activity of antibiotic, plant extract or other antimicrobial agent against Propionibacterium acne.