Heterogeneous catalysts improve stereoselectivity in Grignard reagent reactions with enones, indicating effective synthesis methods.
Highly selective conjugate additions of Grignard reagents to cyclic and linear enones catalyzed by recyclable heterogeneous polysaccharide/nanocopper catalysts are disclosed. The method also allows the synthesis of ketones with an all‐carbon quaternary center. When integrated with catalytic asymmetric tandem reactions using enals and β‐ketoesters, it yields chiral β,δ‐disubstituted ketones with high stereoselectivity.
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Deiana et al. (2025) studied this question.
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