Laboratory study demonstrates efficient allylic substitution of carbonates using reusable cellulose-supported nanocopper, highlighting a sustainable path for Grignard cross-coupling.
Herein, we present a highly efficient allylic substitution of carbonates with Grignard reagents using a reusable cellulose-supported nanocopper catalyst. This approach highlights the first instance of heterogeneous catalysis for the cross-coupling of allylic alcohol substrates with Grignard reagents. The method features high yields, excellent regioselectivity, and complete chirality transfer.
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Mondal et al. (2025) studied this question.
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