Copper-catalyzed allylic substitution of nitroally derivatives with Grignard reagents

Louis Clavier; Stellios Arseniyadis; Laurent El Kaim; Nicolás Fincias

doi:10.1039/d6cc00637j

January 1, 2026Chemical CommunicationsOpen Access

Copper-catalyzed allylic substitution of nitroally derivatives with Grignard reagents

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Key Points

To investigate the allylic substitution of nitroallyl derivatives using Grignard reagents in the presence of copper (I) salts.
Copper (I) salts used as catalysts
Grignard reagents engaged with nitroallyl derivatives
Focus on aryl Grignards for enhanced reactivity.
Successful allylic substitution of nitro groups was achieved
Particularly effective with aryl Grignard reagents
Demonstrates potential for synthetic applications in organic chemistry.

Implication

Reaction reveals effective allylic substitution of nitroallyl derivatives by Grignard reagents, indicating potential for various applications.

Abstract

Grignard reagents engage with nitroallyl derivatives in the presence of copper (I) salts to promote allylic substitution of the nitro group. The reaction is particularly effective with aryl Grignards and...

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Cite This Study

Clavier et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba2618185d8a39802bbe https://doi.org/10.1039/d6cc00637j

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Copper-catalyzed allylic substitution of nitroally derivatives with Grignard reagents

Key Points

Implication

Abstract

Discussion

Cite This Study

Copper-catalyzed allylic substitution of nitroally derivatives with Grignard reagents

Key Points

Implication

Abstract

Discussion

Cite This Study

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