NMDAR‐Antibody Encephalitis Diagnosed With Primary Central Nervous System Lymphoma: A Case Series

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NMDAR encephalitis can indicate an underlying malignancy, exemplified by three patients with concurrent central nervous system lymphoma.
Approximately 38% of NMDAR encephalitis cases have a paraneoplastic association, underlining the importance of early detection.
Detailed clinical features can help identify instances where NMDAR encephalitis and lymphoma coexist, leading to better outcomes.
The findings call for increased awareness of lymphoma as a potential cause in autoimmune encephalitis cases.

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Case series reports coexistence of NMDAR encephalitis and central nervous system lymphoma, suggesting a paraneoplastic relationship.

Ahn et al. (2025) studied this question.

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