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August 11, 2025Cell Death DiscoveryOpen Access

Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions

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Authors

XQXiuxiu QiuShanghai University of Traditional Chinese MedicineAWAo WangGuilin University of Electronic TechnologyJWJiahui WangWannan Medical College

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Overview

Review explores mitochondrial metabolism's role in therapeutic resistance in colorectal cancer, highlighting metabolic vulnerabilities and interventions.

Key Points

  • Mitochondrial metabolic reprogramming contributes to therapeutic resistance in colorectal cancer, impacting treatment effectiveness.
  • Metabolic plasticity and redox balance are emphasized as key factors in CRC cell adaptation to therapy pressures.
  • Assessment of technologies like spatial transcriptomics and patient-derived organoids aids in identifying metabolic vulnerabilities.
  • Targeting mitochondrial rewiring offers a promising approach for developing personalized therapies in CRC.

Cite This Study

Qiu et al. (2025) studied this question.

synapsesocial.com/papers/68a360e70a429f797332972dhttps://doi.org/10.1038/s41420-025-02670-y
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