Crystalloid vs colloid fluid resuscitation in polytrauma patients: a systematic review

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Colloid fluid resuscitation shows no significant advantage over crystalloid fluid regarding 28-day mortality in polytrauma patients.
The analysis included one RCT with 2,857 adult participants, showing no remarkable difference between treatment groups.
The method employed was a systematic review of trials comparing crystalloid and colloid fluids for trauma patients in an ICU setting.
These findings call for further research to determine if one type of fluid improves outcomes in polytrauma cases.

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Systematic review reveals no significant difference in mortality from crystalloid or colloid fluid resuscitation in polytrauma patients.

Dormann et al. (2025) studied this question.

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