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The study aims to assess how different fluid types affect hemodynamics and organ functions in hemorrhagic shock.

April 1, 2026Open Access

Different effects of colloid and crystalloid solutions for fl uid resuscitation on hemodynamics and peripheral organ functions in acute hemorrhagic shock rats

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The study aims to assess how different fluid types affect hemodynamics and organ functions in hemorrhagic shock.
Induced hemorrhagic shock in 48 anesthetized rats by blood withdrawal.
Administered fluid resuscitation with HES, ALB, NS, and 3-NS at specified rates.
Measured changes in hemodynamics, mitochondrial activities, inflammation, and clotting post-resuscitation.
MAP increased significantly in HES and ALB groups compared to NS and 3-NS at 45 min (P < 0.001).
HES and ALB attenuated mitochondrial dysfunction and inflammatory responses effectively.
Colloids induced hemodilution and maintained blood flow, but did not differ in efficacy between HES and ALB.

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Investigates the effects of fluid resuscitation types on organ functions in hemorrhagic shock rats, highlighting implications for treatment.

Ryo et al. (2017) studied this question.

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Investigates the effects of fluid resuscitation types on organ functions in hemorrhagic shock rats, highlighting implications for treatment.