The effect of weight change on death and cardiovascular events after Roux-en-Y gastric bypass

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Cohort study associates weight trajectories with increased mortality and cardiovascular events post-RYGB, suggesting need for intervention.

Increased weight loss after nadir heightens risk of death and major cardiovascular events (MACE).
Of 25,230 patients, 1,276 experienced MACE and 707 died within an average of 10.6 years.
Study followed patients from Sweden who underwent Roux-en-Y gastric bypass from 2007 to 2018, tracking weight changes and outcomes.
Findings indicate that both continuous weight loss after nadir and significant weight regain are linked to adverse outcomes post-surgery.

Stenberg et al. (2025) studied this question.

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Cohort study associates weight trajectories with increased mortality and cardiovascular events post-RYGB, suggesting need for intervention.