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August 14, 2025

Prognostic Value of Lactate/Albumin Ratio and NEWS-Lactate in Predicting Sepsis-Associated Acute Kidney Injury: A Retrospective Analysis.

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Authors

DXDuong Le XuanGHGhi Nguyen HaiVDVu Anh Duc

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Implication

Retrospective analysis shows lactate/albumin ratio predicts acute kidney injury in sepsis, suggesting new biomarkers may improve early detection.

Key Points

  • The lactate/albumin ratio (LAR) demonstrates the highest predictive performance for sepsis-associated acute kidney injury (SA-AKI).
  • With an area under the curve (AUC) of 0.800, LAR shows sensitivity of 70.5% and specificity of 70.3% at a cut-off of 0.101.
  • A retrospective observational study assessed 564 patients with sepsis, comparing biomarkers and clinical characteristics between SA-AKI and non-AKI groups.
  • LAR and NEWS-Lactate are promising biomarkers, indicating potential for early detection compared to traditional severity scores.

Cite This Study

Xuan et al. (2025) studied this question.

synapsesocial.com/papers/68a363670a429f797332ac83https://doi.org/10.22037/aaemj.v13i1.2723
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The elevated lactate dehydrogenase to albumin ratio is a risk factor for developing sepsis-associated acute kidney injury: a single-center retrospective study2024 · 12 citations
  2. 2The Role of Lactate Albumin Ratio as A Prognostic Factor in Sepsis2025
  3. 3Association between lactate to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study from MIMIC-IV database2024 · 2 citations
  4. 4Evaluating the predictive value of initial lactate/albumin ratios in determining prognosis of sepsis patients2024 · 15 citations
  5. 5Association between lactate-to-albumin ratio and 30-day all-cause mortality in patients with acute pancreatitis-associated acute kidney injury2026 · 1 citations