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August 14, 2025Veterinary ResearchOpen Access

PEDV infection downregulates goblet cell differentiation through activating the Notch pathway

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Authors

YWYì WángSYShanshan YangYZYongxiang Zhao

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Overview

Observational analysis reveals PEDV infection reduces goblet cell differentiation in piglets, highlighting disrupted intestinal barrier function.

Key Points

  • PEDV infection impairs intestinal barrier integrity and reduces goblet cell numbers in piglets.
  • Activation of the Notch pathway by PEDV is crucial for hindering goblet cell differentiation.
  • In vitro experiments show that PEDV-encoded ORF3 protein is essential for activating the Notch pathway.
  • Findings indicate significant disruptions to epithelial cell function due to PEDV's interaction with the intestinal environment.

Cite This Study

Wáng et al. (2025) studied this question.

synapsesocial.com/papers/68a363670a429f797332acbchttps://doi.org/10.1186/s13567-025-01599-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PEDV regulates trans-mammary epithelial migration of T cells in a CCR10/CCL28-dependent manner2026
  2. 2Correlation between the barrier function of the intestinal epithelium and susceptibility to PEDV infection in piglets at different ages2026
  3. 3Innate Immune Evasion of Porcine Epidemic Diarrhea Virus Through miRNA‐193a‐5p/IL22/pBD1 Pathway in Intestinal Epithelium2025 · 1 citations
  4. 4Innate Immune Evasion of Porcine Epidemic Diarrhea Virus Through miRNA‐193a‐5p/IL22/pBD1 Pathway in Intestinal Epithelium2025
  5. 5Impact of PEDV infection on the biological characteristics of porcine intestinal exosomes2024 · 2 citations