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July 10, 2026Veterinary ResearchOpen Access

Correlation between the barrier function of the intestinal epithelium and susceptibility to PEDV infection in piglets at different ages

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Authors

YLYabin LuXinjiang Agricultural UniversitySLShuxian LiXinjiang Agricultural UniversitySYShanshan YangWuhan Textile University

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Overview

Randomized trial finds age-related changes in intestinal barrier impact PEDV susceptibility in piglets, suggesting improved resilience with age.

Key Points

  • The study aims to understand how the intestinal development of piglets influences their susceptibility to PEDV infection.
  • Six piglets at various ages (newborn to 8 weeks) were inoculated with PEDV strain LJX01/2014.
  • Piglets were sacrificed 48 hours post-infection for analysis of intestinal changes.
  • Indirect immunofluorescence and immunohistochemistry were used to assess tissue changes.
  • Severe diarrhoea and viral shedding observed in neonatal piglets compared to older piglets.
  • Significantly lower villi/crypt ratios in younger piglets, indicating impaired intestinal structure.
  • Age-related increase in intraepithelial lymphocytes and a decrease in epithelial cells; tissue repair improved with age.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a508d096eeac72a437a0b80https://doi.org/10.1186/s13567-026-01803-0
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