Background Young pigs are often coinfected with porcine circovirus 2 (PCV2) and porcine epidemic diarrhea virus (PEDV). This study aimed to determine the impact of coinfection of pigs with PCV2 and PEDV. Forty 16‐day‐old crossbred mixed‐sex piglets were assigned to four groups ( n = 10/group, NEG‐CONTROL, PCV2‐CONTROL, PCV2+PEDV, and PEDV‐CONTROL). At day postinoculation (dpi) 0, NEG‐CONTROL pigs were inoculated with saline, PCV2‐CONTROL pigs were inoculated with PCV2, PCV2+PEDV pigs were inoculated with PCV2 and PEDV, and PEDV‐CONTROL pigs were inoculated with PEDV. Results No clinical signs were observed in the NEG‐CONTROL and PCV2‐CONTROL group pigs throughout termination of the study at dpi 21. Other than mild to moderate diarrhea, which lasted for about 7 days, no other clinical signs associated with PEDV or PCV2 infection were observed in the PEDV‐CONTROL and PEDV+PCV2 groups. Conclusion Coinfection of PEDV and PCV2 had no effect on virus shedding, serum antibody profile, and macroscopic or microscopic lesions.
Gerber et al. (Thu,) studied this question.