Brain myelin as a deficient energy source in aging and disease

Carlos Matute; Alexei Verkhratsky

doi:10.1016/j.tem.2025.07.006

August 1, 2025Trends in Endocrinology and MetabolismOpen Access

Brain myelin as a deficient energy source in aging and disease

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Key Points

Myelin may serve as an essential energy source for brain metabolism, especially under glucose scarcity.
The article discusses the impact of myelin dysfunction in aging and neurodegenerative diseases.
Proposed metabolic plasticity indicates myelin's role in supporting brain function.
Insights may inform interventions in aging populations and those with neurodegenerative conditions.

Implication

Forum article highlights myelin's consumption and replenishment in managing brain metabolism and aging-related health issues.

Abstract

Central nervous system (CNS) myelin may act as a dynamic energy store that supports brain metabolism; its consumption and replenishment is a newly recognized form of metabolic plasticity aimed at maintaining brain function upon limited glucose supply. In this forum article we propose that myelin dysfunctions may affect human health in aging and neurodegenerative diseases.

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Cite This Study

Matute et al. (2025) studied this question.

synapsesocial.com/papers/68a365600a429f797332b562 https://doi.org/10.1016/j.tem.2025.07.006

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Brain myelin as a deficient energy source in aging and disease

Key Points

Implication

Abstract

Discussion

Cite This Study

Brain myelin as a deficient energy source in aging and disease

Key Points

Implication

Abstract

Discussion

Cite This Study

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