August 15, 2025PULMONOLOGIYAOpen Access

Arterial stiffness and endothelial dysfunction at high altitude

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Authors

INI. R. NurkaevPirogov Russian National Research Medical University DSD. G. SoldatovPirogov Russian National Research Medical University TSTalant SooronbaevNational Center of Cardiology and Internal Medicine

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Implication

Observational analysis reveals endothelial dysfunction and increased arterial stiffness at high altitude in healthy volunteers, highlighting potential cardiovascular risks.

Key Points

Some healthy volunteers experience transient increases in pulmonary artery pressure at high altitude, indicating possible endothelial dysfunction.
At low altitude, participants showed no disturbances in pulmonary hemodynamics, arterial stiffness, or nitric oxide levels.
Assessment used a noninvasive photoplethysmographic method alongside nitric oxide and echocardiography, following a longitudinal design.
Transient changes in hemodynamics and arterial stiffness may suggest risks for developing pulmonary hypertension at high altitudes.

Cite This Study

Nurkaev et al. (2025) studied this question.

synapsesocial.com/papers/68a365740a429f797332bb3e https://doi.org/10.18093/0869-0189-2025-35-4-592-596

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Implication

Observational analysis reveals endothelial dysfunction and increased arterial stiffness at high altitude in healthy volunteers, highlighting potential cardiovascular risks.

Arterial stiffness and endothelial dysfunction at high altitude

Discussion

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Implication

Key Points

Cite This Study

Arterial stiffness and endothelial dysfunction at high altitude

Discussion

Member takes

Implication

Key Points

Cite This Study

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