Why the study?
Does high-altitude exposure impair vascular function and structure in healthy lowlanders compared to sea level and native highlanders?
Population
12 healthy lowlanders and 12 high-altitude natives. A follow-up experiment included 11 healthy lowlanders.
Comparison
Acute and chronic exposure to high altitude for… vs Lowlanders at sea level and highlanders at 5050…
Design
Cohort, placebo-controlled (for follow-up experiment)
Follow-up
12-14 days
Authors
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High-altitude exposure was associated with persistent vascular impairment in lowlanders; leaves open clinical relevance and need for outcome trials.
Does high-altitude exposure impair vascular function and structure in healthy lowlanders compared to sea level and native highlanders?
High-altitude exposure in lowlanders causes persistent impairment in vascular function and increased arterial stiffness, mediated partially via oxidative stress and sympathoexcitation.
Lewis et al. (2013) studied this question.
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