March 1, 2023High Altitude Medicine & Biology
Impact of Oxygen Supplementation on Brachial Artery Hemodynamics and Vascular Function During Ascent to 5,050 m
Why the study?
It was unknown whether high-altitude trekking-induced alterations in upper limb hemodynamics and reductions in brachial artery vascular function are reversible with the removal of hypoxia.
Does 20 minutes of oxygen supplementation alter brachial artery hemodynamics and vascular function in lowlanders during high-altitude ascent?
Population
Participants aged 21-42 years at 3,440 m (n = 7), 4,371 m (n = 7), and 5,050 m (n = 12)
Comparison
20 minutes of oxygen supplementation vs before oxygen supplementation
Design
Physiological study
Authors
Discussion
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Implication
O2 may reduce delivery early in ascent; hypothesis-generating for timing of supplementation in lowlanders.
Structured PICO
Does 20 minutes of oxygen supplementation alter brachial artery hemodynamics and vascular function in lowlanders during high-altitude ascent?
P
Population
Lowlanders aged 21-42 years trekking to high altitude, examined at 3,440 m (n=7), 4,371 m (n=7), and 5,050 m (n=12)
I
Intervention
20 minutes of oxygen supplementation (O2)
C
Comparator
Baseline measurements before oxygen supplementation at the respective altitudes
O
Outcome
Brachial artery hemodynamics, reactive hyperemia (RH; microvascular function), and flow-mediated dilation (FMD; endothelial function)surrogate
Oxygen supplementation during early high-altitude exposure causes upper limb vasoconstriction, but with incremental exposure, it reduces blood flow without compromising oxygen delivery or vascular function.
Cite This Study
Vizcardo‐Galindo et al. (2023) studied this question.