Key result
Acute exposure to hypobaric hypoxia (3842 m) significantly decreased peripheral oxygen saturation and increased cardiac output (143.2% of pre-ascent values, p<0.001) in healthy volunteers.
Why the study?
The study aimed to observe the effects of a fast acute ascent to simulated high altitudes on cardiovascular function in the main arteries and peripheral circulation.
Does acute exposure to hypobaric hypoxia alter cardiovascular function in unacclimatized healthy subjects?
Population
17 healthy volunteers between 18 and 50 years old
Comparison
Sea level vs 3842 m of hypobaric hypoxia vs return to sea level
Design
Hypobaric chamber study
Authors
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Acute hypobaric hypoxia triggers compensatory CO rise despite desaturation in healthy adults; leaves open applicability to patients or real ascents.
Observational (n=17)
Does acute exposure to hypobaric hypoxia alter cardiovascular function in unacclimatized healthy subjects?
Effect estimate: 84.9% of pre-ascent values
p-value: p=<0.001
Acute exposure to hypobaric hypoxia in healthy subjects induces compensatory increases in cardiac output and oxygen delivery while decreasing flow-mediated dilation.
Theunissen et al. (2022) conducted an observational in Healthy (n=17). Acute hypobaric hypoxia exposure vs. Sea level (pre-ascent) was evaluated on Peripheral oxygen saturation (84.9% of pre-ascent values, p=<0.001). Acute exposure to hypobaric hypoxia (3842 m) significantly decreased peripheral oxygen saturation and increased cardiac output (143.2% of pre-ascent values, p<0.001) in healthy volunteers.
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