Key result
Three weeks of chronic hypoxia linked to a ~6% drop in VO2max and reduced cardiac output.
Why the study?
The effects of prolonged exposure to chronic hypoxia on maximal oxygen uptake, cardiac output, and related oxygen transport parameters were investigated.
Does prolonged exposure to chronic hypoxia alter oxygen transport system parameters in human subjects?
Comparison
Before vs 3 weeks after prolonged exposure to chronic hypoxia
Design
Observational study
Follow-up
3 weeks
Authors
Loading...
Chronic hypoxia may limit aerobic capacity; leaves open effects of intermittent exposure or in clinical populations.
Observational (n=6)
Does prolonged exposure to chronic hypoxia alter oxygen transport system parameters in human subjects?
Absolute Event Rate: 4.13% vs 4.39%
p-value: p=<0.05
Prolonged exposure to chronic hypoxia reduces maximal cardiac output and VO2max despite compensatory increases in hemoglobin and hematocrit.
Ferretti et al. (1990) reported an observational. Prolonged exposure to chronic hypoxia vs. Before exposure (baseline) was evaluated on Maximal VO2 on the treadmill (VO2max) in l/min (p=<0.05). Prolonged exposure to chronic hypoxia for 3 weeks reduced VO2max (4.13 vs 4.39 l/min) and maximal cardiac output (16.89 vs 21.81 l/min) compared to baseline (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: