Key result
Ascent to 3,100 m altitude for 10 days caused a 32% decrease in coronary blood flow, offset by a 28% increase in coronary arterial O2 extraction without myocardial hypoxia.
Why the study?
Does a 10-day sojourn at 3,100 m altitude alter coronary blood flow and myocardial oxygen delivery in normal men?
Population
3 normal men native to low altitude
Comparison
10 days' sojourn at 3,100 m altitude vs Baseline at sea level
Design
Cohort
Follow-up
10 days
Authors
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Short-term high-altitude exposure preserves myocardial oxygenation in healthy men; leaves open effects in patients with coronary disease or prolonged sojourns.
Observational (n=3)
Does a 10-day sojourn at 3,100 m altitude alter coronary blood flow and myocardial oxygen delivery in normal men?
Effect estimate: 32% decrease
Adaptation to high altitude involves a decrease in coronary blood flow compensated by increased oxygen extraction, maintaining myocardial oxygenation without hypoxia.
Grover et al. (1976) conducted an observational in Healthy (n=3). Ascent to 3,100 m altitude vs. Sea level was evaluated on Coronary blood flow (32% decrease). Ascent to 3,100 m altitude for 10 days caused a 32% decrease in coronary blood flow, offset by a 28% increase in coronary arterial O2 extraction without myocardial hypoxia.
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