Why the study?
Does exposure to high altitude reduce stroke volume due to diminished venous return or left ventricular dysfunction in young men?
Population
11 young men
Comparison
Exposure to 3100 m altitude for 10 days vs Baseline assessment at sea level
Design
Cohort
Follow-up
10 days
Authors
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Reduced stroke volume at altitude reflects plasma volume contraction, not LV dysfunction; leaves open confirmatory trials in broader populations.
Does exposure to high altitude reduce stroke volume due to diminished venous return or left ventricular dysfunction in young men?
Reduced stroke volume at high altitude is driven by diminished venous return secondary to contracted plasma volume, rather than impaired left ventricular systolic performance.
Alexander et al. (1983) studied this question.
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