Key result
High-altitude exposure reduces stroke volume at rest and during exercise, likely driven by decreased left ventricular end-diastolic volume and altered filling patterns rather than impaired systolic function.
Why the study?
Does high-altitude exposure reduce stroke volume in humans, and what are the underlying mechanisms?
Population
Humans exposed to high altitude (up to and above 5000 m)
Comparison
High-altitude exposure (hypoxic stress) vs Sea-level conditions
Design
Review
Authors
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May warrant caution with high-altitude exertion in patients with diastolic issues; leaves open prospective validation in athletes and patients.
Does high-altitude exposure reduce stroke volume in humans, and what are the underlying mechanisms?
This review highlights that the reduction in stroke volume at high altitude is likely driven by decreased left ventricular end-diastolic volume and altered filling patterns rather than impaired systolic function.
Stembridge et al. (2015) conducted a review in High-altitude exposure. High-altitude exposure vs. Sea level was evaluated. High-altitude exposure reduces stroke volume at rest and during exercise, likely driven by decreased left ventricular end-diastolic volume and altered filling patterns rather than impaired systolic function.
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