Key result
High altitude exposure for 10 days reduced resting stroke volume (60 vs 70 ml) and left ventricular end-diastolic volume (P=0.004) compared to sea level, despite increased resting LV mechanics.
Why the study?
Does high altitude exposure impair intrinsic myocardial performance and limit stroke volume during rest and exercise in healthy participants?
Observational (n=10)
Does high altitude exposure impair intrinsic myocardial performance and limit stroke volume during rest and exercise in healthy participants?
Effect estimate: ~17% lower
Absolute Event Rate: 60% vs 70%
High altitude reduces stroke volume and end-diastolic volume despite enhanced resting left ventricular mechanics, limiting the capacity to further increase stroke volume during exercise.
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High altitude may limit exercise stroke volume via preload despite enhanced LV mechanics; hypothesis-generating for cardiac output at altitude.
Stembridge et al. (2015) conducted an observational in Healthy participants (n=10). High altitude (5,050 m) vs. Sea level (344 m) was evaluated on Resting stroke volume (SV) (~17% lower). High altitude exposure for 10 days reduced resting stroke volume (60 vs 70 ml) and left ventricular end-diastolic volume (P=0.004) compared to sea level, despite increased resting LV mechanics.
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