Key result
Plasma volume expansion in lowlanders after 25-26 days at 3454 m restored stroke volume to sea-level values during head-up tilt (P=0.003), demonstrating that hypovolemia causes the reduced SV.
Why the study?
Does altitude-induced hypovolemia explain the reduced stroke volume in lowlanders?
Population
7 lowlanders
Comparison
Altitude exposure with passive whole body… vs Baseline measurements at sea level
Design
Other
Follow-up
25/26 days
Authors
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Plasma volume expansion may restore stroke volume at altitude; hypothesis-generating for hypovolemia mechanism but requires confirmation before any clinical consideration.
Does altitude-induced hypovolemia explain the reduced stroke volume in lowlanders?
p-value: p=0.003
The reduction in resting stroke volume observed during acclimatization to high altitude is primarily driven by hypovolemia and can be reversed by plasma volume expansion.
Siebenmann et al. (2013) studied Altitude-induced reduction in stroke volume (n=7). Plasma volume expansion vs. Pre-expansion at altitude and sea level baseline was evaluated on Stroke volume during head-up and head-down tilting (p=0.003). Plasma volume expansion in lowlanders after 25-26 days at 3454 m restored stroke volume to sea-level values during head-up tilt (P=0.003), demonstrating that hypovolemia causes the reduced SV.
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