Alterations in left ventricular function in normal man on exposure to high altitude (3658 m).
Why the study?
Does exposure to high altitude (3658 m) alter left ventricular function in normal individuals?
Population
198 normal individuals, comprising 83 normal volunteers exposed to high altitude, 56 permanent residents of…
Comparison
Exposure to high altitude (3658 m) for 10 days. vs Baseline at sea level, permanent residents of…
Design
Cohort
Follow-up
10 days at high altitude, plus return to sea level
Authors
Discussion
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Implication
High-altitude exposure was associated with transient LV depression in healthy subjects; leaves open effects in patients with preexisting cardiac disease.
Structured PICO
Does exposure to high altitude (3658 m) alter left ventricular function in normal individuals?
P
Population
198 normal individuals, comprising 83 normal volunteers exposed to high altitude (3658 m), 56 permanent residents of high altitude, and 59 lowlanders resident at high altitudes for 120 to 180 days.
I
Intervention
Exposure to high altitude (3658 m) for 10 days.
C
Comparator
Baseline at sea level, permanent residents of high altitude, and temporary residents (120 to 180 days).
O
Outcome
Left ventricular function indices (pre-ejection period, left ventricular ejection time, PEP/LVET ratio, RZ interval, contractility index, stroke index, and cardiac index).surrogate
Acute exposure to high altitude causes a transient, reversible depression in left ventricular function in normal individuals.
Cite This Study
Balasubramanian et al. (1978) studied this question.