Why the study?
Does beta methyldigoxin or a diuretic prevent left ventricular dysfunction in normal healthy volunteers exposed to high altitude?
Population
51 normal healthy volunteers at sea level, exposed to 3658 m altitude
Comparison
Beta methyldigoxin or a diuretic vs Placebo
Design
RCT, double blind
Follow-up
10 days
Authors
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May support prophylactic digoxin to preserve cardiac index at high altitude; extends digoxin evidence to acute hypoxic stress in healthy hearts.
Does beta methyldigoxin or a diuretic prevent left ventricular dysfunction in normal healthy volunteers exposed to high altitude?
Prophylactic digoxin administration may prevent high altitude-induced left ventricular dysfunction and reduction in stroke index in healthy individuals.
Balasubramanian et al. (1978) studied this question.
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