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August 15, 2025Open Access

From Wiring to Firing: Collapse of embryonic identities and emergence of functional diversity during motor neuron maturation

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Authors

YCYijia ChenHCHsuan-Ming ChiATAileen Tian

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Overview

Single nucleus sequencing reveals how motor neurons transition from diverse embryonic identities to functional subtypes, highlighting transcriptional changes during maturation.

Key Points

  • Motor neurons undergo significant transcriptional changes as they mature, leading to functional diversity.
  • At embryonic day E15.5, motor neurons are subdivided into dozens of transcriptional subclusters, specific to muscle targets.
  • Single nucleus multiome sequencing was used to analyze transcriptomic and chromatin changes during maturity.
  • The findings suggest that neuron identity is shaped throughout maturation, with both initial diversity and subsequent specialization being key.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68a365740a429f797332be02https://doi.org/10.1101/2025.08.12.669897
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