What question did this study set out to answer?

To resolve the fine molecular subtypes and genetic heterogeneity among limb- and axial-innervating mammalian spinal motor neurons.

January 3, 2023Nature CommunicationsOpen Access

Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons

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Authors

ELEe Shan Liau SJSuoqin Jin YCYen‐Chung Chen

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Overview

Single-cell transcriptomic profiling reveals novel subtypes and neuropeptide codes in mammalian spinal motor neurons, indicating conserved organization across higher vertebrates.

Key Points

To resolve the fine molecular subtypes and genetic heterogeneity among limb- and axial-innervating mammalian spinal motor neurons.
Performed single-cell transcriptomic sequencing on mouse spinal motor neurons to characterize subtype-specific gene expression profiles.
Assessed the conservation of identified transcriptional signatures across mouse, chicken, and human embryonic spinal cords.
Identified a distinct combinatorial neuropeptide code distinguishing putative motor pool identities among limb-innervating motor neurons.
Uncovered three conserved axial motor neuron subtypes defined by mediolaterally-biased Satb2, Nr2f2, and Bcl11b expression with distinct axon guidance profiles across mice, chickens, and humans.

Cite This Study

Liau et al. (2023) studied this question.

synapsesocial.com/papers/6a9e6af88dd5fc7fdbd706b7 https://doi.org/10.1038/s41467-022-35574-x

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January 3, 2023Nature CommunicationsOpen Access

Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons

View Full Paper

Ask AI

Bookmark

Authors

ELEe Shan Liau SJSuoqin Jin YCYen‐Chung Chen

Discussion

Member takes

Overview

Single-cell transcriptomic profiling reveals novel subtypes and neuropeptide codes in mammalian spinal motor neurons, indicating conserved organization across higher vertebrates.

Key Points

To resolve the fine molecular subtypes and genetic heterogeneity among limb- and axial-innervating mammalian spinal motor neurons.
Performed single-cell transcriptomic sequencing on mouse spinal motor neurons to characterize subtype-specific gene expression profiles.
Assessed the conservation of identified transcriptional signatures across mouse, chicken, and human embryonic spinal cords.
Identified a distinct combinatorial neuropeptide code distinguishing putative motor pool identities among limb-innervating motor neurons.
Uncovered three conserved axial motor neuron subtypes defined by mediolaterally-biased Satb2, Nr2f2, and Bcl11b expression with distinct axon guidance profiles across mice, chickens, and humans.

Cite This Study

Liau et al. (2023) studied this question.

synapsesocial.com/papers/6a9e6af88dd5fc7fdbd706b7 https://doi.org/10.1038/s41467-022-35574-x

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