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August 15, 2025Open Access

Go/z-biased coupling profile of the dopamine D3 receptor

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Authors

LZLucia ZanettiLFLuca FranchiniSSShirsha Saha

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Overview

Characterization reveals dopamine D3 receptor activates Go and Gz, but not Gi proteins, suggesting implications for neuropsychiatric therapy.

Key Points

  • Dopamine D3 receptor selectively activates Go and Gz proteins, not Gi, indicating a unique coupling profile.
  • Treatment of hippocampal neurons with agonists showed varying impacts on cAMP levels, with D3R not activating Gi proteins.
  • Observational study using cell-based assays clarified the molecular mechanisms underlying the D3R's selective signaling.
  • Results suggest the need for refined therapeutic strategies for neuropsychiatric disorders targeting the dopamine D3 receptor.

Cite This Study

Zanetti et al. (2025) studied this question.

synapsesocial.com/papers/68a366930a429f797332bedehttps://doi.org/10.1101/2025.08.08.668522
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