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August 16, 2025CureusOpen Access

Comparison of Clinical and Imaging Parameters in Patients With Neuromyelitis Optica Spectrum Disorder and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Prospective Observational Study

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Observational study identifies distinct profiles in NMOSD and MOGAD, highlighting differences in demographics and outcomes.

NMOSD patients present at an older average age (34.67 years) compared to MOGAD patients (26 years), indicating notable demographic differences.
Significantly more optic neuritis cases were seen in MOGAD patients (p = 0.0061), suggesting distinct clinical features related to the disorders.
The study utilized a prospective observational design over 18 months to assess clinical profiles, treatment, and outcomes in both groups of patients.
MOGAD appears to have a better treatment response and lower relapse rates than NMOSD, highlighting important clinical implications for management.

Devi et al. (2025) studied this question.

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