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Detection of Aquaporin 4 Antibody and Myelin Oligodendrocyte Glycoprotein Antibody in Clinically Suspected Neuromyelitis Optica Spectrum Disorders Patients in a Tertiary Eye Hospital

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Observational study found high prevalence of MOG antibodies in patients with atypical optic neuritis, highlighting the need for routine testing.

MOG antibodies were found in 34.8% of patients, indicating a higher prevalence compared to AQP4 positivity.
Severe visual loss occurred in 74.3% of MOG-positive and 76.9% of AQP4-positive patients, showing significant impairment.
This observational analysis involved 184 patients evaluated for clinical symptoms and antibody levels over two years.
Findings suggest routine antibody testing implementation for accurate diagnosis in cases of atypical optic neuritis.

Jinat et al. (2025) studied this question.

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Observational study found high prevalence of MOG antibodies in patients with atypical optic neuritis, highlighting the need for routine testing.