What question did this study set out to answer?

This report aims to describe a rare instance of co-occurring AQP4 and MOG antibodies in a patient with NMOSD.

A Rare Overlap of AQP4 and MOG Seropositivity in Neuromyelitis Optica Spectrum Disorder: A Case Report

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Case report reveals dual seropositivity for AQP4 and MOG antibodies in a woman with NMOSD, highlighting treatment complexities.

This report aims to describe a rare instance of co-occurring AQP4 and MOG antibodies in a patient with NMOSD.
Presented case of a 53-year-old woman with AQP4 and MOG seropositivity and recurrent myelitis.
Cerebrospinal fluid analysis showed lymphocytic pleocytosis; MRI performed to assess central nervous system changes.
Treatment included intravenous immunoglobulin and later rituximab after relapse.
Patient exhibited four episodes of bilateral lower limb sensory deficits and weakness.
MRI revealed significant findings in the spinal cord and brain related to NMOSD.
Post-rituximab treatment led to clinical stability despite antibody persistency.

Butler et al. (2026) studied this question.

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