Demyelinating Disease with MOG Autoantibody Positive and Optic Neuritis

A BSTRACT Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system inflammatory demyelinating disease characterized by recurrent inflammatory events which primarily involve optic nerves and the spinal cord, which occur either simultaneously or sequentially. The aquaporin-4 antibody (AQP4-IgG) is specific for NMOSD. Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been found in a group of AQP4-IgG-negative patients. NMOSD is characterized by severe attacks, poor recovery, and high relapse rates, leading to rapid disability. Hence, early diagnosis and management is very important. In this report, we present a case of a 12-year-old girl with MOG Positive NMOSD with radiological findings in her magnetic resonance imaging (MRI) brain with spine.