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August 16, 2025Frontiers in Cell and Developmental BiologyOpen Access

MiR-145-5p arrests the cell cycle by modulating SMAD5/cyclin D1 to inhibit gastric cancer progression

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Authors

LWLi WangShanxi Medical UniversityJGJianghong GuoCLCaixia LvShanxi Medical University

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Implication

Observational analysis revealed lower miR-145-5p levels in gastric cancer, indicating its role in cell cycle control and proliferation.

Key Points

  • Overexpression of mir-145-5p significantly inhibits gastric cancer cell proliferation and leads to cell cycle arrest from G1 to S phase.
  • miR-145-5p expression was found to be lower in gastric cancer tissues compared to adjacent tissues, correlating with poor patient prognosis.
  • Bioinformatics analysis identified cyclin D1 as a target gene of smad5, which is regulated by miR-145-5p in gastric cancer cells.
  • The findings may support the use of the miR-145-5p/SMAD5/cyclin D1 axis as a prognostic biomarker for gastric cancer treatment.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68a368710a429f797332d075https://doi.org/10.3389/fcell.2025.1619359
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  3. 3Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers2016 · 11 citations
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