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November 14, 2025Scientific ReportsOpen Access

MiR-5095 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting CEACAM5

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Authors

WLWan LinRCRuizhi CaiWFWeining Fan

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Overview

Experimentally, miR-5095 reduces tumor growth and metastasis in gastric cancer, suggesting its potential as a therapeutic target.

Key Points

  • To explore the role of miR-5095 in gastric cancer progression and its mechanisms of action.
  • Cell proliferation, migration, and invasion were assessed using various assays including CCK-8 and transwell assays.
  • Expression levels of miR-5095 and CEACAM5 were determined by RT-qPCR and western blotting.
  • Bioinformatic tools predicted target interactions, confirmed by luciferase assays.
  • In vivo experiments were conducted using a xenograft mouse model.
  • miR-5095 expression was significantly lower in gastric cancer tissues than in normal tissues.
  • In vitro overexpression of miR-5095 inhibited proliferation, migration, and invasion of gastric cancer cells.
  • CEACAM5 expression was elevated in gastric cancer, and its overexpression reversed miR-5095's inhibitory effects.
  • miR-5095 significantly inhibited tumor growth and metastasis in the xenograft model.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/692519a7c0ce034ddc354103https://doi.org/10.1038/s41598-025-23669-6
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