August 16, 2025

Primary Cutaneous Anaplastic Large Cell Lymphoma with Locoregional Lymph Node Involvement: Challenges in Diagnosis and Clinical Management.

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Discussion

Case analysis reveals lymph node involvement complicates diagnosis of PC-ALCL, suggesting improved staging methods are needed.

Diagnosis involves integrating clinical and histopathological findings, enhancing accuracy and management strategies.
Histological features were consistent across skin and lymph node biopsies in the newly reported cases.
Both cases of PC-ALCL with lymph node involvement were treated successfully with brentuximab vedotin chemotherapy.
Highlighting the critical need for thorough clinical staging underscores the complexities in diagnosing PC-ALCL.

García et al. (2025) studied this question.

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