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December 8, 2025BloodOpen Access

Determinants of survival in primary cutaneous anaplastic large cell lymphoma (pcALCL): Analysis of a real-world pooled database

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Authors

AGAnkita Gupta

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Overview

A pooled analysis reveals prognostic factors and treatment modalities influencing survival in pcALCL patients, indicating a need for tailored management.

Key Points

  • This analysis explores the demographic and clinicopathologic determinants of survival in primary cutaneous anaplastic large cell lymphoma.
  • Compiled a pooled database of real-world cases diagnosed with pcALCL
  • Excluded cases with LYP or MF
  • Constructed Kaplan-Meier survival curves
  • Used Cox proportional hazards model and Log-rank tests to assess survival factors
  • Identified 189 patients with median age of 55 years
  • ALK- status, multiple lesions, and ulceration negatively affected overall survival
  • Increased overall survival observed with therapeutic interventions like Radiation and Chemotherapy
  • Recurrence occurred in 49% of patients, primarily cutaneous
  • DUSP22+ was associated with better disease-free survival and overall survival

Cite This Study

Ankita Gupta (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2dehttps://doi.org/10.1182/blood-2025-5411
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Also Consider

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  1. 1Abstract 3833: Primary cutaneous diffuse large B-cell lymphoma-leg type and clinicopathologic determinants of survival: Analysis of a pooled database2024
  2. 2Outcomes of primary cutaneous anaplastic large cell lymphoma across u.S. cancer care settings: A national cancer database analysis.2025
  3. 3Primary Cutaneous Anaplastic Large Cell Lymphoma: A Review of Diagnosis and Treatment for the General Oncologist2026
  4. 4Primary Cutaneous Anaplastic Large Cell Lymphoma with Locoregional Lymph Node Involvement: Challenges in Diagnosis and Clinical Management.2025
  5. 5Diagnostic and management challenges in primary cutaneous anaplastic large cell lymphoma with necrosis, inflammation, and surgical intervention: A case report2024