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July 23, 2026Pediatric Blood & Cancer

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

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Authors

SGShoshana GreenbergerEBEfrat Bar‐IlanMVMarcu V

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Overview

Case series reveals genomic diversity in pediatric primary cutaneous anaplastic large cell lymphoma, indicating implications for treatment outcomes.

Key Points

  • This research aims to explore the genomic drivers of pediatric primary cutaneous anaplastic large cell lymphoma (pcALCL).
  • Case series of three children with skin-limited pcALCL
  • Analysis of genomic fusions including NPM::ALK, NUP214::FRK, and PICALM::JAK2
  • Follow-up duration ranged from 31 to 50 months.
  • All patients achieved durable complete remission without progression
  • Clinical courses varied from spontaneous regression to systemic therapy
  • Identified novel genomic fusions contribute to the understanding of pcALCL.

Cite This Study

Greenberger et al. (2026) studied this question.

synapsesocial.com/papers/6a61af56faa9903c5116a369https://doi.org/10.1002/1545-5017.70437
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