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November 30, 2025JAMA Dermatology

JAK2 Fusions in Adult Patients With Mycosis Fungoides and CD30 Lymphoproliferative Disorders

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JAK2 fusions were found in 43 patients with cutaneous T-cell lymphoma, indicating potential importance in diagnosis.
88.4% of patients had mycosis fungoides or CD30-positive lymphoproliferative disorders, suggesting commonality of fusions.
Identified through targeted sequencing, these alterations may highlight the role of JAK2 in CTCL progression.
The findings support the need for JAK2 targeting therapies, especially in early-stage mycosis fungoides.

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Retrospective analysis identifies JAK2 fusions in cutaneous T-cell lymphoma and CD30-positive disorders, highlighting their diagnostic significance.

Geller et al. (2025) studied this question.

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Retrospective analysis identifies JAK2 fusions in cutaneous T-cell lymphoma and CD30-positive disorders, highlighting their diagnostic significance.