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December 8, 2025BloodOpen Access

Outcomes of primary cutaneous anaplastic large cell lymphoma across u.S. cancer care settings: A national cancer database analysis.

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Authors

EKErin KaserThe University of Texas Health Science Center at San AntonioSKSupreet KaurBarrow Neurological Institute

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Overview

Retrospective analysis shows survival outcomes similar for primary cutaneous anaplastic large cell lymphoma at academic and community programs.

Key Points

  • To analyze demographics, treatment patterns, and outcomes of primary cutaneous anaplastic large cell lymphoma across different care settings.
  • Conducted a retrospective analysis of PC-ALCL cases reported to the National Cancer Database from 2004 to 2022.
  • Compared demographic, clinical, and survival data between patients treated at academic (ACPs) and community cancer programs (CCPs).
  • Utilized Kaplan-Meier and Cox proportional hazards models to compare overall survival after adjusting for relevant variables.
  • Identified a total of 2,618 patients with PC-ALCL, with 1,523 treated at ACPs and 822 at CCPs.
  • Survival analysis indicated no significant survival advantage for ACPs over CCPs (p=0.72).
  • Patients at ACPs were generally younger but had a longer median time-to-treatment compared to those at CCPs.

Cite This Study

Kaser et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2dfhttps://doi.org/10.1182/blood-2025-5419
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A national analysis on ALK+ anaplastic large cell lymphomas: Community-based care linked to similar survival outcomes compared to academic centers.2025
  2. 2The academic center effect: Better outcomes for patients with DLBCL2025
  3. 3Determinants of survival in primary cutaneous anaplastic large cell lymphoma (pcALCL): Analysis of a real-world pooled database2025
  4. 4Facility-level disparities in outcomes of subcutaneous panniculitis-like T-cell lymphoma: A national cancer database analysis2025
  5. 5Unequal outcomes: The role of institutional setting in the management of primary CNS lymphoma2025 · 1 citations