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August 16, 2025

Associations between epilepsy-related polygenic risk and brain morphology in childhood.

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Authors

ANAlexander NgoLLL W LiuSLSara Larivière

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Overview

Population-based analysis links polygenic risk for hippocampal sclerosis to brain morphology and network architecture.

Key Points

  • Higher polygenic risk for hippocampal sclerosis was linked to reductions in cortical thickness across specific brain regions, including temporo-parietal areas.
  • Analysis of brain structure in 3,826 neurotypical children using MRI revealed significant correlations between genetic risk and cortical atrophy.
  • Employing genome-wide genotyping alongside structural imaging allows insights into genetic influences on brain morphology relating to epilepsy.
  • Findings suggest a replicable connection between genetic vulnerability and disease mechanisms in patients with temporal lobe epilepsy, highlighting early intervention potentials.

Cite This Study

Ngo et al. (2025) studied this question.

synapsesocial.com/papers/68a3688b0a429f797332db45https://doi.org/10.1093/brain/awaf259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biophysically informed large-scale circuit modeling reveals regionspecific microscale dynamics in temporal lobe epilepsy2026
  2. 2Duration-dependent hippocampal structural changes in focal epilepsy: multicenter neuroimaging evidence.2026
  3. 3Large-scale imaging genetics reveals causal effects of brain microstructure across the epilepsy spectrum2026
  4. 4Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy2024 · 26 citations
  5. 5Revealing brain network hierarchy and molecular correlates in temporal lobe epilepsy: A multimodal neuroimaging study2026