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August 17, 2025The Journal of Pediatric Pharmacology and Therapeutics

Use of Intrapleural Alteplase in the Treatment of Parapneumonic Effusion in Children: A Report of a 10-year Experience

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Authors

YGYusuf M. GarwanMedical University of South CarolinaMAMuath A. AlsalloumMedical University of South CarolinaATA. Jill ThompsonMedical University of South Carolina

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Overview

Retrospective analysis found no significant difference in treatment failure rates with lower or higher alteplase doses in children with PPE, suggesting effective dosing strategies.

Key Points

  • Lower doses of alteplase (≤2 mg) were effective for most children with parapneumonic effusion, with a 14% treatment failure rate.
  • The higher dose group had a median chest tube output of 346 mL/24h, significantly more than the lower dose group's 175 mL/24h.
  • Assessment of patient records from July 2014 to May 2023 covered 72 children, analyzing treatment outcomes and hospital course.
  • Combining alteplase with video-assisted thoracoscopic surgery may lead to reduced lengths of hospital and intensive care unit stays.

Cite This Study

Garwan et al. (2025) studied this question.

synapsesocial.com/papers/68a36a360a429f797332e40bhttps://doi.org/10.5863/jppt-24-00057
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  1. 1The role of the early video-assisted thoracoscopic surgery in children with pleural empyema2024 · 18 citations