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Scoping review assesses cannabinoids' effectiveness in managing orofacial pain and highlights the need for further research.
Background: Safe, effective cannabinoids from Cannabis Sativa L. show promise as complementary therapy for chronic/acute pain, inflammation, anxiety, and sleep disorders. Objective: The aim of this study is to conduct a comprehensive review of the literature on the use of cannabinoids in the management of orofacial pain. Methods: This scoping review investigates the use of cannabinoids to treat orofacial pain. It focused on scientific articles published in indexed journals with no date limit from PubMed/MEDLINE. Researchers defined a guiding question ("treatment with cannabinoids for orofacial pain?") and excluded non-centralized studies, editorials, and non-indexed journals. Reviewers independently selected studies and extracted key data for further analysis. Results: Although 833 articles were considered, only 11 met criteria (mostly recent systematic reviews). These studies originated from various countries with a focus on research from the past few years (2021-2022). Conclusion: Cannabinoids show promise for orofacial pain due to pain relief and inflammation reduction, but more research is needed.
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Arato et al. (2025) studied this question.
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