Cannabinology in Dentistry: Therapeutic Applications and Future Directions

Cannabinology, the study of compounds derived from Cannabis sativa and their interactions with the endocannabinoid system (ECS), has gained increasing relevance in dentistry. Cannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) demonstrate therapeutic potential in the management of orofacial pain, dental anxiety, periodontal inflammation, and tissue regeneration [1,2]. This narrative review explores the biological basis of cannabinoid action in oral tissues, clinical applications, regulatory challenges, and future perspectives for cannabinoid-based therapies in dental practice [3]. Despite promising preliminary evidence, more robust clinical trials are needed to establish safety, efficacy, and standardized therapeutic protocols [4]. The integration of cannabinology into dental education and research can expand the therapeutic arsenal available to oral health professionals.