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May 22, 2026BiomedicinesOpen Access

Cannabidiol in Periodontal Therapy—Is There Hope or Just a Bias? A Systematic Review

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Authors

RȘRuxandra ȘtefănescuATAmelia Tero-VescanCVCamil-Eugen Vari

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Overview

Systematic review evaluates cannabidiol's role in modulating periodontal inflammation and microbial activity, suggesting further research is needed.

Key Points

  • The review aims to assess the potential of cannabidiol in managing periodontal disease through its anti-inflammatory and antimicrobial properties.
  • Conducted a systematic literature search across multiple databases including Web of Science and PubMed.
  • Included studies focusing on CBD's effects on periodontal inflammation, biofilms, and bone remodeling.
  • Reviewed preclinical and clinical studies in accordance with PRISMA guidelines.
  • CBD modulates inflammatory signaling pathways, inhibiting TLR4/NF-κB and reducing pro-inflammatory cytokines.
  • Animal studies showed reduced alveolar bone loss and decreased osteoclast activity with CBD treatment.
  • CBD demonstrated antimicrobial and antibiofilm activity against oral microorganisms.

Cite This Study

Ștefănescu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff362d674f7c03778bf3bhttps://doi.org/10.3390/biomedicines14051163
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic Potential of Cannabidiol in Dysbiosis-Related Oral Biofilm Diseases: Antibiofilm, Antivirulence and Host Response Evidence2026
  2. 2Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis2026
  3. 3Contribution of Resveratrol on Periodontal Disease Control and Treatment: A Systematic Review.2026
  4. 4Endocannabinoid system dysregulation in oral diseases: mechanistic insights and therapeutic modulation2026
  5. 5Cannabinology in Dentistry: Therapeutic Applications and Future Directions2025 · 1 citations