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August 17, 20250 citationsOpen Access

Liver Single-Nucleus Multiome Profiling Reveals Mechanisms for Cardiometabolic Traits

Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits

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Authors

AAAbdalla A AlkhawajaKCKevin W. CurrinHPHannah J. Perrin

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Overview

Multiome profiling uncovers gene regulation pathways in liver cell types, suggesting implications for cardiometabolic health.

Key Points

  • Chromatin accessibility QTLs (caQTLs) identified regulatory regions influencing cardiometabolic traits.
  • Integration of multiome data from 39 individuals revealed 68,398 nuclei across six cell types in the liver.
  • Single-nucleus techniques highlighted previously unnoticed regulatory mechanisms, including those in liver endothelial cells.
  • This research enhances understanding of genetic traits influencing liver function in relation to cardiometabolic health.

Cite This Study

Alkhawaja et al. (2025) studied this question.

synapsesocial.com/papers/68a36dd20a429f7973330bc6https://doi.org/10.1101/2025.08.06.668997
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