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May 31, 2026Bioinformatics0 citationsOpen Access

Genomics-Informed Approach Identifies Regulatory Cell Types for Metabolite Levels

Genomics-Informed Approach Identifies Which Cell Types Regulate the Metabolome

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Authors

HKHaim KrupkinStanford UniversityEPEvin M. PadhiStanford UniversityDNDaniel NachunStanford University

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Overview

Randomized trial identifies cell types regulating metabolites in a body-wide analysis, suggesting new associations.

Key Points

  • This research aims to determine which cell types are responsible for regulating metabolite levels throughout the body.
  • Integrated metabolite quantitative trait loci datasets from TOPMed and UK Biobank.
  • Combined these with single-cell RNA sequencing data from Tabula Sapiens.
  • Analyzed associations between cell types and metabolites.
  • Hepatocytes regulate 94% of metabolites (385/410) with identified associations.
  • Multi-gene analysis revealed more metabolite associations with beta cells than single-gene approaches.
  • Novel associations, such as phenylpropanoic acid linked to beta cells, were identified.
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Cite This Study

Krupkin et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd2ab5783ba022b6fe27fhttps://doi.org/10.1093/bioinformatics/btag330
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