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December 10, 2025BMC Genomics0 citationsOpen Access

Exploring Epigenetic Control and Metabolic Identity Across Different Cell Types

Epigenetic control of metabolic identity across cell types

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Authors

MPMaria Pires PachecoDGDéborah GerardRMRiley J. Mangan

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Overview

Integrative analysis defines metabolic networks in human cell types, indicating epigenetic control by transcription factors.

Key Points

  • This research aims to explore the epigenetic control over metabolic identity across different cell types.
  • Utilized RNA-seq and epigenomic data from the EpiATLAS resource.
  • Reconstructed metabolic networks for 1,555 samples across 58 tissues and cell types.
  • Analyzed the distribution of metabolic functionalities and identified cell type-specific functions.
  • Defined core and unique metabolism contributing to the metabolic identity of cells and tissues.
  • Identified key regulatory nodes and enhancers affecting core and unique metabolism.
  • Found evidence of Polycomb-mediated repression in inactive metabolic pathways.

Cite This Study

Pacheco et al. (2025) studied this question.

synapsesocial.com/papers/69401d542d562116f28f8a28https://doi.org/10.1186/s12864-025-12155-y
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Also Consider

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  1. 1Epigenetic control of metabolic identity across cell types2025
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  4. 4Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits2025
  5. 5A transcriptomic and proteomic map of primary human cell types2025