LEGO-inspired pipette-free approach for fully-integrated molecular diagnostic kit isothermally operated at near body temperature for the detection of antibacterial resistance

Kieu The Loan Trinh; So Yeon Park; Hyunji Lee; Nae Yoon Lee

doi:10.1039/d5an00628g

January 1, 2025The Analyst

LEGO-inspired pipette-free approach for fully-integrated molecular diagnostic kit isothermally operated at near body temperature for the detection of antibacterial resistance

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Key Points

The device achieves rapid detection of antibacterial resistance without the need for pipettes, enhancing usability and accessibility.
It utilizes DNA extraction and isothermal amplification through LAMP, providing a streamlined process for diagnosis.
This integrated microdevice employs colorimetric detection to visualize results effectively and quickly.
The approach may revolutionize molecular diagnostics by making it easier for non-specialists to perform tests outside traditional lab settings.

Implication

Innovative device enables rapid identification of antibacterial resistance using LAMP and colorimetric detection.

Abstract

Herein, we introduce a LEGO-inspired molecular diagnostic microdevice fully integrated with DNA extraction, loop-mediated isothermal amplification (LAMP), and colorimetric detection functionalities for rapid detection of antibacterial resistance in a pipette-free...

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Cite This Study

Trinh et al. (2025) studied this question.

synapsesocial.com/papers/68a36dd20a429f7973330c96 https://doi.org/10.1039/d5an00628g

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LEGO-inspired pipette-free approach for fully-integrated molecular diagnostic kit isothermally operated at near body temperature for the detection of antibacterial resistance

Key Points

Implication

Abstract

Discussion

Cite This Study

LEGO-inspired pipette-free approach for fully-integrated molecular diagnostic kit isothermally operated at near body temperature for the detection of antibacterial resistance

Key Points

Implication

Abstract

Discussion

Cite This Study

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