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Review compares alveoli healing outcomes post-extraction with and without platelet-rich fibrin, suggesting enhanced recovery.
The healing of the alveoli after extraction is an essential process in the recovery of patients after tooth extractions. The use of platelet-rich fibrin (PRF) has been proposed as an effective method to accelerate this process and improve bone regeneration. This review aims to analyze and compare the results of post-extraction alveoli healing with and without the application of PRF, based on recent clinical trials and data from the literature. The use of platelet-rich fibrin (PRF) in bone regeneration after tooth extractions offers significant clinical advantages. PRF facilitates the gradual release of essential growth factors, such as PDGF (platelet-derived growth factor), TGF-β (transforming growth factor beta), and VEGF (vascular endothelial growth factor), stimulating the proliferation and differentiation of osteoprogenitor cells essential for the formation of new bone. The fibrin matrix provides a three-dimensional scaffold, supporting cell migration and attachment, thus improving the structural organization of tissue in healing. PRF significantly improves angiogenesis by promoting the formation of new blood vessels, ensuring a constant supply of oxygen and nutrients to the regenerated bone.
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Grigore et al. (2024) studied this question.
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